Examples of increased muscle hypertrophy are seen in various professional sports , mainly strength related sports such as boxing , olympic weightlifting , mixed martial arts , rugby , professional wrestling and various forms of gymnastics . Athletes in other more skill-based sports such as basketball , baseball , ice hockey , and soccer may also train for increased muscle hypertrophy to better suit their position of play. For example, a center (basketball) may want to be bigger and more muscular to better overpower his or her opponents in the low post.  Athletes training for these sports train extensively not only in strength but also in cardiovascular and muscular endurance training.
The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany,    for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.  Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years.  Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.