Corticosteroids, including prednisone, are a class of powerful drugs that reduce inflammation and suppress the immune system. They are prescribed for a wide variety of conditions, including rheumatoid arthritis (RA) and lupus, as well as multiple sclerosis, some types of cancer, asthma and skin rashes – including those caused by poison ivy. They can be prescribed short-term – until a rash clears up or until another drug can take effect, for example – or they may be used long-term. Corticosteroids come in skin creams, injections and inhaled forms; however, this study examined only people who took them orally.
Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.
The belowing negative reactions, presented by system body organ class in alphabetical order, have been recognized during post approval use of Bentyl. Since these responses are stated willingly from a populace of uncertain dimension, it is not always possible to accurately approximate their frequency or set up a causal connection to medication exposure.
Instances of thrombophlebitis, shot and thrombosis website responses such as local discomfort, edema, skin color adjustment and also even reflex considerate dystrophy disorder have actually been reported belowing inadverent IV shot of Bentyl.
Peripheral Nervous System: With overdosage, a curare-like activity might happen (i. e. neuromuscular blockade bring about muscular weakness and also feasible paralysis).
Other: lowered sweating, sneezing, throat congestion, impotence. With the injectable kind, there might be momentary sensation of light-headedness. Some regional irritation as well as focal coagulation necrosis could take place complying with the intramuscular injection of Bentyl.
Anticholinergics annoy the effects of antiglaucoma representatives. When taken concurrently with brokers such as corticosteroids, anticholinergic medicines in the visibility of increased intraocular pressure might be harmful. Usage of Bentyl in individuals with glaucoma is not advised [see Contraindications (4)]
Over The Counter Bentyl. Bentyl Pills.
The following agents might boost certain actions or negative side effects of anticholinergic medications consisting of Bentyl: amantadine, antiarrhythmic representatives of Class I (e. g. quinidine), antihistamines, antipsychotic agents (e. g. phenothiazines), benzodiazepines, MAO preventions, narcotic anesthetics (e. g. meperidine), nitrites and also nitrates, sympathomimetic agents, tricyclic antidepressants, and various other drugs having anticholinergic tactics.