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Steroid isolation , depending on context, is the isolation of chemical matter required for chemical structure elucidation, derivitzation or degradation chemistry, biological testing, and other research needs (generally milligrams to grams, but often more  or the isolation of "analytical quantities" of the substance of interest (where the focus is on identifying and quantifying the substance (for example, in biological tissue or fluid). The amount isolated depends on the analytical method, but is generally less than one microgram.  [ page needed ] The methods of isolation to achieve the two scales of product are distinct, but include extraction , precipitation, adsorption , chromatography , and crystallization . In both cases, the isolated substance is purified to chemical homogeneity; combined separation and analytical methods, such as LC-MS , are chosen to be "orthogonal"—achieving their separations based on distinct modes of interaction between substance and isolating matrix—to detect a single species in the pure sample. Structure determination refers to the methods to determine the chemical structure of an isolated pure steroid, using an evolving array of chemical and physical methods which have included NMR and small-molecule crystallography .  : 10–19 Methods of analysis overlap both of the above areas, emphasizing analytical methods to determining if a steroid is present in a mixture and determining its quantity. 
Now, there is also a case that the league should leave the ball mostly alone. As it is, the commissioner's office is mostly free from blame when offense goes up or down, but if it took an active role in changing the baseball it might be stuck "owning" every swing in the offensive environment. The imprecision of baseball construction -- there can be a lot of variation from batch to batch, and small variations can make a big difference -- might open the league up to all sorts of unintended consequences. As Lindbergh told me by email Wednesday, "As intensely as a small subset of analysts pays (and draws) attention to changes in the game, a rising home run rate isn't something most fans would fixate on unless you gave them a reason to. Tell them that the ball is different, and they might decide that they don't like things this way and blame MLB for tampering with a game that they love, especially since statistics and adherence to tradition are a big part of baseball's appeal."