Hematological effects of steroids

Zinc intoxication may cause anemia by blocking the absorption of copper from the stomach and duodenum . [2] Zinc also upregulates the expression of chelator metallothionein in enterocytes , which are the majority of cells in the intestinal epithelium. [2] Since copper has a higher affinity for metallothionein than zinc, the copper will remain bound inside the enterocyte, which will be later eliminated through the lumen . [2] This mechanism is exploited therapeutically to achieve negative balance in Wilson’s disease , which involves an excess of copper. [2]

There is a simple lack of iron in this disorder. It is the most prevalent nutritional disorder in the United States. The cause could be the result of poor dietary intake of iron sources. Age and financial status have an influence in this disorder with 25% of children 6–24 months of age in the low socioeconomic population having a diagnosis of anemia. Adolescents are at risk due to rapid growth needs and inadequate nutritional eating practices. Premature and multiple birth babies have reduced fetal iron supplies, making them at risk of iron deficiency anemia. Other causes are associated factors include

"Leprosy reactional states" can commonly occur as a result of effective treatment for leprosy. They are generally classified into two types: reversal reactions (type 1) and erythema nodosum leprosum (ENL or type 2). Reversal reactions primarily occur in borderline or tuberculoid leprosy patients soon after the initiation of chemotherapy and consist of fever and swelling of existing skin and nerve lesions. Acute neuritis may develop. ENL occurs mostly in lepromatous patients (approximately 50% of treated patients within the first year) and a small number of borderline patients. Manifestations include fever and tender erythematous skin nodules sometimes associated with malaise, neuritis, orchitis, albuminuria, joint swelling, iritis, epistaxis or depression. In addition, skin lesions may become pustular and/or ulcerate. Histologically, there is vasculitis with an intense polymorphonuclear infiltrate. In general, antileprosy treatment is continued. Patients with severe reactions require hospitalization. Therapeutic management for reversal reactions may include administration of analgesics and/or corticosteroids and surgical decompression of swollen nerve trunks. Analgesics, corticosteroids, and other agents may be used for ENL reactions. For guidance concerning the management of reactional states, the Gillis W. Long Hansen's Disease Center in Carville, Louisiana (tel: 800-642-2477) should be contacted. [ Ref ]

The most frequent adverse reactions to Efudex occur locally and are often related to an extension of the pharmacological activity of the drug. These include burning, crusting, allergic contact dermatitis , pruritus , scarring, rash, soreness, and ulceration . Ulcerations, other local reactions, cases of miscarriage and a birth defect ( ventricular septal defect ) have been reported when Efudex was applied to mucous membrane areas. Leukocytosis is the most frequent hematological side effect. Although a causal relationship is remote, other adverse reactions which have been reported infrequently are:

Hematological effects of steroids

hematological effects of steroids

The most frequent adverse reactions to Efudex occur locally and are often related to an extension of the pharmacological activity of the drug. These include burning, crusting, allergic contact dermatitis , pruritus , scarring, rash, soreness, and ulceration . Ulcerations, other local reactions, cases of miscarriage and a birth defect ( ventricular septal defect ) have been reported when Efudex was applied to mucous membrane areas. Leukocytosis is the most frequent hematological side effect. Although a causal relationship is remote, other adverse reactions which have been reported infrequently are:

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