No carcinogenic potential was demonstrated in mice treated subcutaneously with octreotide for 85-99 weeks at doses up to 2000 mcg/kg/day (8x the human exposure based on body surface area ). In a 116-week subcutaneous study in rats administered octreotide, a 27% and 12% incidence of injection site sarcomas or squamous cell carcinomas was observed in males and females, respectively, at the highest dose level of 1250 mcg/kg/day (10x the human exposure based on body surface area) compared to an incidence of 8%-10% in the vehicle-control groups. The increased incidence of injection site tumors was most probably caused by irritation and the high sensitivity of the rat to repeated subcutaneous injections at the same site. Rotating injection sites would prevent chronic irritation in humans. There have been no reports of injection site tumors in patients treated with Sandostatin Injection for at least 5 years. There was also a 15% incidence of uterine adenocarcinomas in the 1250 mcg/kg/day females compared to 7% in the saline -control females and 0% in the vehicle-control females. The presence of endometritis coupled with the absence of corpora lutea, the reduction in mammary fibroadenomas, and the presence of uterine dilatation suggest that the uterine tumors were associated with estrogen dominance in the aged female rats which does not occur in humans.
Can I ask, not to get anyone in trouble, but is the only way to get a hold of actual testosterone thru a physician? I know it’s prescribed, but for me, I can’t pursue that really.
I’ve tried to befriend guys at the gym, who could possibly have access to roids, but that’s not panned-out to get me connected. It’s a difficult thing to explain, but i’m not a Trans-male, but someone who was born with a condition called Klinefelter Syndrome, meaning I was born male, but later learned I was born with an extra X chronsome, and it puts me on the XXY gender spectrum. About 1 in 500 male births qualify as XXY. I’m of normal intelligence, though people with the disorder tend to be of less-than-average IQs,and have a feminine body for a man, and had gynecomastia and removal surgery for that. It’s been a very difficult road for me, and, as you can imagine, it’s a difficult life to manage. To sort of weirdly complicate my own life, I only ever attended boy’s Catholic schools, so, you can guess how that played out. I often have been mistaken for a girl, and have had the three-times-repeated experience of being at a gay bar, and asked if I was a trans-woman, meaning that I was born and raised as a woman, but transitioned to a male appearance. It’s odd then, when i’ve wanted to become more male in appearance. I have low testosterone, but that is not something you can ask a doctor to help you resolve. They don’t seem to get it, and it’s incredibly hard for me to pursue myself. And I want to be in control of my own body, and not given a thumbs-up or thumbs-down, or suffer through the process of constantly being under the microscope. And then as a gay man, who does not look “GQ-ready”, is a terrible thing to go through. I turned to you guys, I guess because you could sort of relate. Thanks and thanks for listening.
Although potentially serious allergic adverse reactions such as anaphylactic shock may occur rarely during, or shortly after, parenteral administration of Pabrinex Intramuscular, such rare occurrence of serious allergic reactions should not preclude the use of Pabrinex Intramuscular in patients who need treatment by this route of administration. Initial warning signs of a reaction to Pabrinex Intramuscular are sneezing or mild asthma, and those treating patients need to note that the administration of further injections to such patients may give rise to anaphylactic shock. Facilities for treating anaphylactic reactions should be available whenever Pabrinex Intramuscular High Potency is administered.