The exercise consisted of treadmill running, five days a week for 60 minutes per session for six weeks. Compared to the sedentary mice getting the placebo, the mice that didn’t exercise but were given mesterolone showed significant elevations of triglycerides (blood fat) total cholesterol, LDL and VLDL (a precursor of LDL). When exercise was added, the mice were higher in HDL and lower in VLDL and triglycerides. The exercise also increased blood flow in the heart, but that effect was slightly reduced in the mice on steroids. While exercise alone produced favorable effects in heart muscle structure and function, they were was blocked in the steroid mice. The net effect is that while doing aerobic exercise may partially reduce a few of the major cardiovascular risk factors raised by steroid use, steroids also interfere with the favorable changes in heart muscle structure induced by aerobic exercise. Studies of men using Proviron for six months show similar negative cardiovascular risk factor changes—lower HDL, increased LDL and total cholesterol.
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