12. It is accepted that some years after the filing date of the patent in suit, some steroid hormone analogues were indeed shown to interfere with AP-1 stimulated transcription as required for the steroid hormone of claim 6. To the board, however, it can only mean that it took a few years of research work possibly involving inventive step and, therefore, undue burden, to put the claimed subject-matter into practice ie to structurally identify the relevant product(s) and show a potential effect in therapy. Even then, the corresponding use as a pharmaceutical was suggested rather than shown (see point 6, supra).
Bridging. When you bridge the problem is you never come off steroids. You run a 12 week cycle and then for the next 6 to 8 weeks you are running a oral steroid or a low dose of Testosterone. Where does your body have to work on its own, this long on steroids and your body now forgets how to produce its own Testosterone, the side effects never get to reside. We all no oral steroids can cause liver problems, if tylenol can send a person to the hospital for liver damage then so can these steroids. When you use them in a cycle, you can just run them, get off and your body repairs, but when you bridge your body does not get that chance.