Steroid hormones act by binding to receptors that are located where

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

While steroids have a number of benefits, they also have a number of negative effects. There are many side effects associated with anabolic steroid use. The first is kidney and liver damage. These are the two organs responsible for removing toxins from the body and maintaining homeostasis; a state of balance in the body. When you introduce foreign substances, such as steroids, into the body, these organs will try to break then down and get rid of them. The result will be damage to these organs. Hair loss , mood swings, severe acne and development of man boobs are some of the side effects of using steroids.

Steroid hormones act by binding to receptors that are located where

steroid hormones act by binding to receptors that are located where

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