Drugs that work on your immune system. Your doctor may consider these medicines -- such as azathioprine, cyclosporine, or methotrexate -- if other treatments don’t help. There are also prescription creams and ointments that treat eczema by controlling inflammation and reducing immune system reactions. Examples include pimecrolimus (Elidel), which is a cream, and crisaborole (Eucrisa) and tacrolimus (Protopic), which are ointments. You should only use these for a short time if other treatments don't work -- and you should never use them on kids younger than 2, according to the FDA.