It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Females can have a very hard time with anabolic steroid supplementation, as many anabolic steroids can lead to virilization symptoms. Of course, there are some anabolic steroids that carry a much lower rate of virilization, and while Winstrol is not the lowest it is on the list. There will be many women who tolerate this hormone quite well, and as such display no adverse reactions. Of course, as we're all unique individuals some will have a problem even at a low dose. In most cases, a dosing of 10mg every other day will be all the Winstrol any woman needs; some will tolerate 20mg every other day, but understand this significantly increases the risk of virilization. At any rate, use should in most cases never surpass 6 weeks, and regardless of dose you must exercise caution. If at any time you begin to show negative symptoms, simply discontinue use immediately and you'll see them quickly fade away. If you fail to heed to this warning, you may find the symptoms make a permanent home.